Simon, Ming Yuen LEE 李銘源

Chair Professor
Department of Food Science and Nutrition
The Hong Kong Polytechnic University
Academic Qualifications
  • BSc (Hon), City University of Hong Kong
  • PhD, The Chinese University of Hong Kong
Teaching
Edu. Courses
  • 2017-present   Nutrition and Food Safety (GEST1018)
  • 2011-2014        Wonders in Life Science and Health: Biomedical Science
  • 2009-2011       Biology I (EDSE202)
  • 2009-2011       Biology II (EDSE203)
Sc. Courses
  • 2014-present    Systems Biology (CMED719)
  • 2006-present   Pharmacology and Safety Evaluation (MCMC101)
  • 2004-2014        Biotechnology (MCMC105)
  • 2004-2007       Development of New Drugs and Health Products (MCMC102)
  • 2004-2007       Medical Information Technology (MCMC106)
PhD Courses
  • 2013-present    Quality Research in Chinese Medicine (CMED809)
  • 2013-2015         University Teaching I
  • 2013-2014         Healthcare Decision Analysis
Research Interests
  • Biochemistry of cancer, cardiovascular and neurodegenerative diseases
  • Molecular pharmacology of Chinese medicine
  • Systems biology: genome, transcriptome, proteome and protein interaction network
Brief introduction

Simon’s research interests lie in the discovery of drug-like agents from natural products including small molecule and biologics for use in various therapeutic areas, including cardio-cerebrovascular diseases and brain disorders. He also developed cutting-edge drug screening technologies, including genomics and zebrafish disease models, which have made an impact in terms of the discovery of new therapeutic agents from natural products. His dedication to education and research in the fields of pharmacology and toxicology has leaded to over 300 scholarly articles, including Nature Genetics and Nature Communications (4×), supervision of 60+ postgraduates (>20 PhD) and over ten granted patents.

He is a life member of Clare Hall, University of Cambridge and has been granted honorary professorship by various universities around the world. He has served as a committee member for different professional associations (e.g. Chair of Council, Macau Pharmacology Association; Executive President, Consortium of ‘Belt and Road’ and Portuguese-Speaking Countries for Natural Medicine Innovation (Macao); Committee Member of Neuropsychopharmacology, and Committee Member of Pharmacology on Traditional Chinese Medicine and Natural Medicine, Chinese Pharmacological Society; Cooperation Partner, WHO Collaborating Centre for Traditional Medicine, Health Bureau of Macao SAR government; Technical Expert of Accreditation Assessment for the Innovation and Technology Commission of Hong Kong SAR government).

He is the founder of a “BioEdu” program, which has received financially support from the Education and Youth Affairs Bureau (Macau SAR Government) for the past 10 years (2007-present), to provide a broad range of science education services, including training workshops on cutting edge biotechnology, to over 40,000 teacher and student participants in Macau. Also, his research on “Application of zebrafish in drug screening for treatment of cardiovascular diseases” was selected as one of the most popular research projects during an activity entitled “Science is by your side: Vote for Your Favorite Local Science Researches”, held at Macao Science Center in 2009, which eventually has developed into a “ZebraEdu” outreach program. He also founded “ISWEEEP” (The International Sustainable World Energy, Engineering, and Environment Project Olympiad)” and Macau Young Scientist (MYS) program at Macao Regional Science Fair since 2016.

Science Outreach
BioEdu Programme 澳門普及生物技術教學實驗計劃

Provide science education support to local schools (e.g. science workshop for students and teacher training).
Resources:

  1. Biotechnology laboratory manuals

https://portal.dsedj.gov.mo/www/portalspace/discuz/redirect.php?tid=1624&goto=lastpost

  1. 澳門中小學校推行之科普實驗教學活動手冊十週年紀念活動 (2009-2018 年)

Editor-in-chief: LEE Ming Yuen
Publication Date: 2018 June
Please download here.

 

ZebraEdu and Macau STEAM Lab 思巴模式生物科普計劃 及 澳門STEAM實踐基地

Develop STEAM education to the community.

Resources:

  1. 果蠅俠-[果蠅模式生物普叢書1]

Executive Editor: LEE Ming Yuen
Publication Date: 2020 July; ISBN: 978-99937-691-8-7
Introduction video:

Audio book: https://youtu.be/e9JLtyoxZTQ
Theme song: https://youtu.be/EzYyTM-rk1E

  1. 祺祺斑馬魚歷險記-啟程編 [斑馬魚科普叢書1]

Executive Editor: LEE Ming Yuen
Publication Date: 2018 January; ISBN: 978-99985-344-0-9
Introduction video:

Book video: https://youtu.be/FuWcFjkpkok (Chinese); https://youtu.be/5FYtcpxbdgI (English)
Theme song: https://youtu.be/FapFLti1SIA

  1. 澳門普及生物技術教學實驗手冊 : 斑馬魚在醫藥研究的應用/

Science explorer biotechnology laboratory manual for Macau secondary schools: zebrafish as a model for human disease and drug discovery
Editor-in-chief: LEE Ming Yuen
Publication Date: 2017 June; ISBN: 978-99937-691-5-6
Please download here.

  1. UM Eco-Map

Map introducing common plants and animals in the University of Macau with recommended visiting routes
The map can be downloaded here.

The 3rd Macau Young Scientists (MYS) Conference (2021)
  • MYS
  • MYS conference 2021 rules-June

 

I-SWEEEP Macau (2016-2018) and MYS Conference (2019-onwards)

Provide Young Scientists (aged: 12-20) in Macao with:

  1. STEAM-themed workshop in local and neighbouring region
  2. mentorship to develop their own scientific innovation or research project
  3. opportunity to participate in different international science competitions or fairs
Selected Publications
Omics and Cross-disciplinary Collaboration
  1. Yuan Y, Zhang Y, Zhang P, Liu C, Wang J, Gao H, Hoelzel AR, Seim I, Lv M, Lin M, Dong L, Gao H, Yang Z, Caruso F, Lin W, da Fonseca RR, Wang D, Wang X, Rasmussen MH, Liu M, Zheng J, Zhao L, Campos PF, Kang H, Iversen M, Song Y, Guo X, Guo J, Qin Y, Pan S, Xu Q, Meng L, A Y, Liu S, Lee SM, Liu X, Xu X, Yang H, Fan G, Wang K, Li S. Comparative genomics provides insights into the aquatic adaptations of mammals. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2106080118. (IF= 12.291, MULTIDISCIPLINARY SCIENCES, Rank’g: 8/73)
  2. Gao C, Huang Q, Liu C, Kwong CHT, Yue L, Wan JB, Lee SM*, Wang R*. Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines. Nat Commun. 2020 May 26;11(1):2622. (IF=12.353; MULTIDISCIPLINARY SCIENCES, Rank’g: 3/64)
  3. Zhao YP, Fan G, Yin PP, Sun S, Li N, Hong X, Hu G, Zhang H, Zhang FM, Han JD, Hao YJ, Xu Q, Yang X, Xia W, Chen W, Lin HY, Zhang R, Chen J, Zheng XM, Lee SM, Lee J, Uehara K, Wang J, Yang H, Fu CX, Liu X, Xu X, Ge S. Resequencing 545 ginkgo genomes across the world reveals the evolutionary history of the living fossil. Nat Commun. 2019 Sep 13;10(1):4201. (IF=12.353; MULTIDISCIPLINARY SCIENCES, Rank’g: 3/64)
  4. Gao C, Huang Q, Lan Q, Feng Y, Tang F, Hoi MPM, Zhang J, Lee SM*, Wang R*. A user-friendly herbicide derived from photo-responsive supramolecular vesicles. Nat Commun. 2018.9: 2967 (IF=12.353; MULTIDISCIPLINARY SCIENCES, Rank’g: 3/64)
  5. Zhang Q*, Zhang H, Sun L, Fan G, Ye M, Jiang L, Liu X, Ma K, Shi C, Bao F, Guan R, Han Y, Fu Y, Pan H, Chen Z, Li L, Wang J, Lv M, Zheng T, Yuan C, Zhou Y, Lee SM, Yan X, Xu X, Wu R*, Chen W*, Cheng T. The genetic architecture of floral traits in the woody plant Prunus mume. Nat Commun. 2018 Apr 27;9(1):1702. (IF=12.353; MULTIDISCIPLINARY SCIENCES, Rank’g: 3/64)
  6. Lamichhaney S, Fan G, Widemo F, Gunnarsson U, Thalmann DS, Hoeppner MP, Kerje S, Gustafson U, Shi C, Zhang H, Chen W, Liang X, Huang L, Wang J, Liang E, Wu Q, Lee SM, Xu X, Höglund J, Liu X, Andersson L. Structural genomic changes underlie alternative reproductive strategies in the ruff (Philomachus pugnax). Nat Genet. 2016 Jan;48(1):84-8. (IF=29.3; GENETICS & HEREDITY, Rank’g: 2/171)
Neurodegeneration and Brain Disorders
  1. Zhou H, Li S, Li C, Yang X, Li H, Zhong H, Lu JH, Lee SM*. Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection via Activation of Immunoproteasome. Aging Dis. 2020 May 9;11(3):559-574. (IF= 5.506, GERIATRICS & GERONTOLOGY, Rank’g: 4/51)
  2. Liao Q, Feng Y, Yang B, Lee SM*. Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease. Drug Discovery Today. 2019 Jan;24(1):189-197. (IF=6.848; PHARMACOLOGY & PHARMACY, Rank’g: 11/261)
  3. Zhou H, Shao M, Guo B, Li C, Lu Y, Yang X, ShengnanLi, Li H, Zhu Q, Zhong H, Wang Y, Zhang Z, Lu J, Lee SM*. Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models. Neurotherapeutics. 2019 Oct;16(4):1225-1236. (IF= 6.453, CLINICAL NEUROLOGY, Rank’g: 21/204)
  4. Li Cw, Bian Yq, Feng Y, Tang F, Wang L, Hoi MP, Ma D, Zhao C, Lee SM*. Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization. ACS Chemical Neuroscience. 2019 May 15;10(5):2434-2449. (IF=4.211, NEUROSCIENCE, Rank’g: 14/90)
  5. Shen S, Liao Q, Liu J, Pan R, Lee SM, Lin L. Myricanol rescues dexamethasone‐induced muscle dysfunction via a sirtuin 1‐dependent mechanism. Journal of Cachexia Sarcopenia and Muscle. 2019 Apr;10(2):429-444. (IF=9.374, GERIATRICS & GERONTOLOGY, Rank’g: 1/53)
  6. Li C, Chen T, Zhou H, Feng Y, Hoi MPM, Ma D, Zhao C, Zheng Y, Lee SM*. BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB. Front Pharmacol. 2018 Jun 25;9:614. (IF=3.831; PHARMACOLOGY & PHARMACY, Rank’g: 48/261)
  7. Li C, Chen T, Zhou H, Zhang C, Feng Y, Tang F, Hoi MP, He C, Zheng Y, Lee SM. Schisantherin A Attenuates Neuroinflammation in Activated Microglia: Role of Nrf2 Activation Through ERK Phosphorylation. Cell Physiol Biochem. 2018;47(5):1769-1784. (IF=4.354, PHYSIOLOGY, Rank’g: 8/83)
  8. Liao Q, Li S, Siu SWI, Morlighem JRL, Wong CTT, Wang X, Rádis-Baptista G, Lee SM*.Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish. Archives Of Toxicology. 2019 Jan;93(1):189-206. (IF= 6.044; TOXICOLOGY, Rank’g: 7/93)
  9. Hung CH, Cheng SS, Cheung YT, Wuwongse S, Zhang NQ, Ho YS, Lee SM, Chang RC*. A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration. Redox Biology, 2017;14: 7-19. (IF=7.126; BIOCHEMISTRY & MOLECULAR BIOLOGY, Rank’g: 31/292)
  10. Luo D, Zhao J, Cheng Y, Lee SM, Rong J. N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson’s Disease and in MPP(+)-Induced Neurons via Promoting the Conversion of proNGF to NGF. Mol Neurobiol. 2018 Mar;55(3):2258-2267. (IF=3.895; CELL BIOLOGY, Rank’g: 74/190)
  11. Law HC, Szeto SS, Quan Q, Zhao Y, Zhang Z, Krakovska O, Lui LT, Zheng C, Lee SM, Siu KW, Wang Y, Chu IK. Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia. J Proteome Res. 2017 Mar 3;16(3):1150-1166. (IF=3.95; BIOCHEMICAL RESEARCH METHODS, Rank’g: 14/79)
  12. Zhang C, Li C, Chen S, Li Z, Jia X, Wang K, Bao J, Liang Y, Wang X, Chen M, Li P, Su H, Wan JB, Lee SM, Liu K, He C. Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hermetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways. Redox Biol. 2017 Apr;11:1-11. (IF=7.126; BIOCHEMISTRY & MOLECULAR BIOLOGY, Rank’g: 31/292)
  13. Chong CM, Ma D, Zhao C, Franklin RJ, Zhou ZY, Ai N, Li C, Yu H, Hou T, Sa F, Lee SM*. Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+/MPTP-induced neuronal death in multiple experimental models. Free Radic Biol Med. 2015 Dec;89:1057-66. (IF=5.7; ENDOCRINOLOGY & METABOLISM, Rank’g: 17/143 )
  14. Zhang Z, Li G, Szeto SSW, Chong CM, Quan Q, Huang C, Cui W, Guo B, Wang Y, Han Y, Michael Siu KW, Lee SM, Chu IK. Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease. Free Radic Biol Med. 2015 Jul;84:331-343. (IF= 6.401; ENDOCRINOLOGY & METABOLISM, 21/145)
  15. Chong CM, Shen M, Zhou ZY, Pan P, Hoi PM, Li S, Liang W, Ai N, Zhang LQ, Li CW, Yu H, Hou T*, Lee SM*.Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP(+)-induced oxidative stress and cell death in SH-SY5Y cells. Free Radical Biology and Medicine. 2014 Sep;74:283-93.. (IF=5.710; ENDOCRINOLOGY & METABOLISM, Rank’g: 15/123 Top:12.20%)
Cardio and cerebrovascular diseases
  1. Yu G, Lee SM, Li CW. Studying the Time Course of Cardiac Responses of the Same Zebrafish Using Scalable Fish-Dock Microarchitecture[J]. Sensors and Actuators B: Chemical, 2018 Sep,268:245-254. (IF=5.667; INSTRUMENTS & INSTRUMENTATION, Rank’g: 2/61)
  2. Cui G, Xin Q, Tseng HHL, Hoi MP, Wang Y, Yang B, Choi I, Wang Y, Yuan R, Chen K, Cong W, Lee SM*. A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice. Pharmacol Res. 2018 Jun 8;134:109-117. (IF=4.897; PHARMACOLOGY & PHARMACY, Rank’g: 21/261)
  3. Yang BR, Yuen SC, Fan GY, Cong WH, Leung SW, Lee SM*. Identification of certain Panax species to be potential substitutes for Panax notoginseng in hemostatic treatments. Pharmacol Res. 2018 May 15;134:1-15. (IF=4.897; PHARMACOLOGY & PHARMACY, Rank’g: 21/261)
  4. Zhou ZY, Huang B, Li S, Huang XH, Tang JY, Kwan YW, Hoi PM, Lee SM*. Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish. Toxicol Appl Pharmacol. 2018 Jul 1;350:32-42. (IF=3.616; TOXICOLOGY, Rank’g: 19/94)
  5. Huang B, Zhou ZY, Li S, Huang XH, Tang JY, Hoi MPM, Lee SM*. Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility. Pharmacol Res. 2018 Feb;128:389-398. (IF=4.897; PHARMACOLOGY & PHARMACY, Rank’g: 21/261)
  6. Li S, Ai N , Shen MY, Dang YY, Chong CM, Pan PC, Kwan YW, Chan SW, Leung GP, Hoi MP, Hou TJ and Lee SM*. Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin. Cell Death Discovery. 2017 Aug 21;3:17051.
  7. Yew WW, Chan DP, Leung CC, Zhang Y, Wang R, Ng P, Lee SM. Can toxicities induced by antituberculosis drugs be better managed in diabetic patients?. European Respiratory Journal. 2017 Jul 1;50(1):1700409. (IF=12.242; RESPIRATORY SYSTEM, Rank’g: 3/59)
  8. Cui G, Ho AW, Lee SM, Wang Y, Hoi MPM*. Development of the novel antiplatelet agent ADTM, originating from traditional Chinese medicine: a chemical proteomic analysis and in-vivo assessment of efficacy in an animal model. The Lancet (2016), 388, S37. (IF = 53.254; MEDICINE, GENERAL & INTERNAL, Rank’g: 2/154).
  9. Li S, Dang YY, Che GO, Kwan YW, Chan SW, Leung GP, Lee SM*, Hoi MPM*. VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. Toxicology and Applied Pharmacology. 2014;280(3);408-420(IF=3.630; TOXICOLOGY, Rank’g: 16/87 Top:18.39%)
Nanotechnology and Drug Delivery
  1. Tao J, Wei Z, He Y, Yan X, Lee SM, Wang X, Ge W, Zheng Y. Toward understanding the prolonged circulation and elimination mechanism of crosslinked polymeric micelles in zebrafish model. Biomaterials. 2020 Oct; 256:120180. (IF= 10.317, ENGINEERING, BIOMEDICAL, Rank’g: 4/87)
  2. Gao C, Cheng Q, Wei JW, Sun C, Lu SY, Kwong CHT, Lee SM, Zhong ZY, Wang RB. Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery. Materials Today, 2020 Jul. (IF= 32.072, MATERIALS SCIENCE, MULTIDISCIPLINARY, Rank’g: 9/314)
  3. Huang Q, Kuok KI, Zhang X, Yue L, Lee SM, Zhang J, Wang R. Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor. Nanoscale. 2018 Jun 7;10(22):10333-10336. (IF=7.233; PHYSICS, APPLIED, Rank’g: 15/146)
  4. Li Y, Song X, Yi X, Wang R, Lee SM, Wang X, Zheng Y. Zebrafish: A Visual Model To Evaluate the Biofate of Transferrin Receptor-Targeted 7Peptide-Decorated Coumarin 6 Micelles. ACS Appl Mater Interfaces. 2017 Nov 8;9(44):39048-39058. (IF= 8.694; MATERIALS SCIENCE, MULTIDISCIPLINARY, Rank’g: 27/293)
  5. Zhang J, Li J, Shi Z, Yang Y, Xie X, Lee SM, Wang Y, Leong KW, Chen M. pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities. Acta Biomater. 2017 Aug;58:349-364. (IF=6.383; MATERIALS SCIENCE, BIOMATERIALS, Rank’g: 3/33)
  6. Ko CN, Yang C, Lin S, Li S, Dong Z, Liu J, Lee SM, Leung CH, Ma DL. A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation. Biosens Bioelectron. 2017 Aug 15;94:575-583. (IF=8.173; CHEMISTRY, ANALYTICAL, Rank’g: 2/80)
  7. Chen T, Li C, Li Y, Yi X, Wang R, Lee SM, Zheng Y. Small-Sized mPEG-PLGA Nanoparticles of Schisantherin A with Sustained Release for Enhanced Brain Uptake and Anti-Parkinsonian Activity. ACS Appl Mater Interfaces. 2017 Mar 22;9(11):9516-9527. (IF=8.097; NANOSCIENCE & NANOTECHNOLOGY, Rank’g: 15/92)
  8. Li Y, Miao X, Chen T, Yi X, Wang R, Zhao H, Lee SM, Wang X, Zheng Y. Zebrafish as a visual and dynamic model to study the transport of nanosized drug delivery systems across the biological barriers. Colloids Surf B Biointerfaces. 2017 Aug 1;156:227-235. (IF= 3.997; BIOPHYSICS, Rank’g: 13/72)
  9. Ma J, Lee SM, Yi C, Li CW. Controllable synthesis of functional nanoparticles by microfluidic platforms for biomedical applications – a review. Lab Chip. 2017 Jan 17;17(2):209-226. (IF=5.995; BIOCHEMICAL RESEARCH METHODS, Rank’g: 5/79)
  10. Gao C, Tang F, Gong G, Zhang J, Hoi MPM, Lee SM, Wang R. pH-Responsive prodrug nanoparticles based on a sodium alginate derivative for selective co-release of doxorubicin and curcumin into tumor cells. Nanoscale. 2017 Aug 31;9(34):12533-12542. (IF=7.233; PHYSICS, APPLIED, Rank’g: 15/146)
  11. Chen TK, Li Y, Li CW, Yi X, Wang RB, Lee SM, Zheng Y. Pluronic P85/F68 Micelles of Baicalein Could Interfere with Mitochondria to Overcome MRP2-Mediated Efflux and Offer Improved Anti-Parkinsonian Activity. Mol Pharm. 2017 Oct 2;14(10):3331-3342. (IF=4.556; MEDICINE, RESEARCH & EXPERIMENTAL, Rank’g: 24/133)
  12. Liu JB, Yang C, Ko CN, Vellaisamy K, Yang B, Lee SM, Leung CH, Ma DL. A long lifetime iridium (III) complex as a sensitive luminescent probe for bisulfite detection in living zebrafish. Sensors and Actuators B: Chemical. 2017 May 31;243:971-6. (IF=5.667; INSTRUMENTS & INSTRUMENTATION, Rank’g: 2/61)
  13. Dong ZZ, Lu L, Ko CN, Yang C, Li S, Lee SM, Leung CH, Ma DL. A MnO 2 nanosheet-assisted GSH detection platform using an iridium (iii) complex as a switch-on luminescent probe. Nanoscale. 2017;9(14):4677-82. (IF=7.233; PHYSICS, APPLIED, Rank’g: 15/146)
  14. Chen T, Li C, Li Y, Yi X, Lee SM, Zheng Y. Oral Delivery of a Nanocrystal Formulation of Schisantherin A with Improved Bioavailability and Brain Delivery for the Treatment of Parkinson’s Disease. Mol Pharm. 2016 Nov 7;13(11):3864-3875.(IF=4.57; MEDICINE, RESEARCH & EXPERIMENTAL, Rank’g: 24/133)
  15. Miao X, Li Y, Wang X, Lee SM, Zheng Y. Transport Mechanism of Coumarin 6 Nanocrystals with Two Particle Sizes in MDCKII Monolayer and Larval Zebrafish. ACS Appl Mater Interfaces. 2016 May 25;8(20):12620-30. (IF=8.097; NANOSCIENCE & NANOTECHNOLOGY, Rank’g: 15/92)
  16. Zhang J, Li C, Zhang R, Zhang F, Liu W, Liu X, Lee SM, Zhang H. A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo. Chem Commun (Camb). 2016 Feb 14;52(13):2679-82. (IF=6.8; CHEMISTRY, MULTIDISCIPLINARY, Rank’g: 28/171)
  17. Mao Z, Wang M, Liu J, Liu LJ, Lee SM, Leung CH, Ma DL. A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish. Chem Commun (Camb). 2016 Mar 25;52(24):4450-3. (IF=6.8; CHEMISTRY, MULTIDISCIPLINARY, Rank’g: 28/171)
  18. Ma DL*, He HZ, Zhong HJ, Lin S, Chan DSH, Wang L, Lee SM, Leung CH, Wong CY*. Visualization of Zn2+ Ions in Live Zebrafish Using a Luminescent Iridium(III) Chemosensor. ACS Applied Materials & Interfaces. 2014 Aug 27;6(16):14008-15. (IF=5.008, MATERIALS SCIENCE, MULTIDISCIPLINARY Rank’g: 26/241, Top: 10.79%)
Marine and Environment
  1. Guo M, Liu G, Chen J, Ma J, Lin J, Fu Y, Fan G, Lee SM*, Zhang L. Dynamics of bacteriophages in gut of giant pandas reveal a potential regulation of dietary intake on bacteriophage composition. Sci Total Environ. 2020 Sep 10;734:139424. Epub 2020 May 19. Erratum in: Sci Total Environ. 2021 Oct 1;789:148661. (IF= 6.551, ENVIRONMENTAL SCIENCES, Rank’g: 22/265)
  2. Hu D, Lee SM-Y, Li K, Mok KM. Secondary Metabolite Production Potential of Mangrove-Derived Streptomyces olivaceus. Marine Drugs. 2021; 19(6):332. (IF= 4.877, CHEMISTRY, MEDICINAL, Rank’g: 16/61)
  3. Gong GY, Kam HT, Tse YC, Giesy JP, Seto SW, Lee SM*. Forchlorfenuron (CPPU) causes disorganization of the cytoskeleton and dysfunction of human umbilical vein endothelial cells, and abnormal vascular development in zebrafish embryos. Environmental Pollution. 2021 Feb 15;271:115791. (IF= 6.939, ENVIRONMENTAL SCIENCES, Rank’g: 21/265)
  4. Zhang PJ, Zhao Y, Li C, Lin ML, Dong LJ, Zhang R, Liu MZ, Li K, Zhang H, Liu XC, Zhang YL, Yuan Y, Liu H, Seim I, Sun S, Du X, Chang Y, Li FD, Liu SS, Lee, SM, Wang K, Wang D, Wang XY, McGowen MR, Jefferson TA, Olsen MT, Stiller J, Zhang GJ, Xu X, Yang HM, Fan GY, Liu X, Li SH. An Indo-Pacific humpback dolphin genome reveals insights into chromosome evolution and the demography of a Vulnerable species. iScience, 2020 Oct 3;23(10):101640; (IF= 4.452, MULTIDISCIPLINARY SCIENCES, Rank’g: 15/71)
  5. Hu D, Sun C, Jin T, Fan G, Mok KM, Li K, Lee SM*. Exploring the Potential of Antibiotic Production From Rare Actinobacteria by Whole-Genome Sequencing and Guided MS/MS Analysis. Front Microbiol. 2020 Jul 15;11:1540. (IF= 4.926, MICROBIOLOGY, Rank’g: 34/135)
  6. He Y, Chang Y, Bao L, Yu M, Li R, Niu J, Fan G, Song W, Seim I, Qin Y, Li X, Liu J, Kong X, Peng M, Sun M, Wang M, Qu J, Wang X, Liu X, Wu X, Zhao X, Wang X, Zhang Y, Guo J, Liu Y, Liu K, Wang Y, Zhang H, Liu L, Wang M, Yu H, Wang X, Cheng J, Wang Z, Xu X, Wang J, Yang H, Lee SM, Liu X, Zhang Q, Qi J. A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth. Mol Ecol Resour. 2019 Sep;19(5):1309-1321. (IF=7.488; BIOCHEMISTRY & MOLECULAR BIOLOGY, Rank’g: 40/297)
  7. Gong G, Kam H, Tse Y, Lee SM*. Cardiotoxicity of forchlorfenuron (CPPU) in zebrafish (Danio rerio) and H9c2 cardiomyocytes. Chemosphere. 2019 Jun 18;235:153-162. (IF= 5.089, ENVIRONMENTAL SCIENCES, Rank’g: 32/250)
  8. Liao Q, Gong G, Poon TCW, Ang IL, Lei KMK, Siu SWI, Wong CTT, Rádis-Baptista G, Lee SM*. Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia). Archives of Toxicology. 2019 Jun;93(6):1745-1767. (IF=6.044, TOXICOLOGY, Rank’g: 7/93)
  9. Fan G, Zhang Y, Liu X, Wang J, Sun Z, Sun S, Zhang H, Chen J, Lv M, Han K, Tan X, Hu J, Guan R, Fu Y, Liu S, Chen X, Xu Q, Qin Y, Liu L, Bai J, Wang O, Tang J, Lu H, Shang Z, Wang B, Hu G, Zhao X, Zou Y, Chen A, Gong M, Zhang W, Lee SM, Li S, Liu J, Li Z, Lu Y, Sabir JSM, Sabir MJ, Khan M, Hajrah NH, Yin Y, Kristiansen K, Yang H, Wang J, Xu X, Liu X. The first chromosome-level genome for a marine mammal as a resource to study ecology and evolution. Mol Ecol Resour. 2019 Jul;19(4):944-956. (IF=7.488; BIOCHEMISTRY & MOLECULAR BIOLOGY, Rank’g: 40/297)
  10. Li FN, Jiang ZK, Liu SW, Tuo L, Lee SM, Sun CH. Marmoricola mangrovicus sp. nov., an endophytic actinobacterium isolated from Kandelia candel. Int J Syst Evol Microbiol.2019(IF=1.932, MICROBIOLOGY, Rank’g: 87/126)
  11. Hu D, Gao C, Sun C, Jin T, Fan G, Mok KM, Lee SM*. Genome-guided and mass spectrometry investigation of natural products produced by a potential new actinobacterial strain isolated from a mangrove ecosystem in Futian, Shenzhen, China. Sci Rep. 2019 Jan 29;9(1):823. (IF=4.122, MULTIDISCIPLINARY SCIENCES , Rank’g: 12/64)
  12. Guo M, Chen Ji, Li Q, Fu Y, Fan G, Ma J, Peng L, Zeng L, Chen J, Wang Y, Lee SM*. Dynamics of Gut Microbiome in Giant Panda Cubs Reveal Transitional Microbes and Pathways in Early Life. Frontiers in microbiology, 9, 3138. (IF=4.019, MICROBIOLOGY , Rank’g: 32/126)
  13. Li W, Li Y J, Lee SM, Mok KM, Hao T. Nitrogen Removal in Moving Bed Sequencing Batch Reactors with Polyurethane Foam Cube and Luffa Sponge Carrier Materials. Journal of Environmental Engineering. 2019, 145(6): 04019025. (IF=1.72, ENGINEERING, CIVIL, Rank’g: 67/132)
  14. Li FN, Liao S, Guo M, Tuo L, Yan X, Li W, Jin T, Lee SM, Sun CH. Mangrovicella endophytica gen. nov., sp. nov., a new member of the family Aurantimonadaceae isolated from Aegiceras corniculatum. Int J Syst Evol Microbiol. 2018 Sep;68(9):2838-2845. (IF=1.932, MICROBIOLOGY, Rank’g: 87/126)
  15. Liao Q, Gong G, Siu SWI, Wong CTT, Yu H, Tse YC, Rádis-Baptista G, Lee SM*. A Novel ShK-Like Toxic Peptide from the Transcriptome of the Cnidarian Palythoa caribaeorum Displays Neuroprotection and Cardioprotection in Zebrafish. Toxins (Basel). 2018 Jun 12;10(6). (IF= 4.009, FOOD SCIENCE & TECHNOLOGY, Rank’g: 19/135)
  16. Hu D, Chen Y, Sun C, Jin T, Fan G, Liao Q, Mok KM, Lee SM*. Genome guided investigation of antibiotics producing actinomycetales strain isolated from a Macau mangrove ecosystem. Scientific reports, 2018, 8(1): 14271. (IF=4.122, MULTIDISCIPLINARY SCIENCES , Rank’g: 12/64)
  17. R L Morlighem JÉ, Huang C, Liao Q, Braga Gomes P, Daniel Pérez C, de Brandão Prieto-da-Silva ÁR, Lee SM, Rádis-Baptista G. The Holo-Transcriptome of the Zoantharian Protopalythoa variabilis (Cnidaria: Anthozoa): A Plentiful Source of Enzymes for Potential Application in Green Chemistry, Industrial and Pharmaceutical Biotechnology. Marine Drugs. 2018 Jun 13;16(6). (IF= 4.446, CHEMISTRY, MEDICINAL, Rank’g: 15/61)
  18. Li FN, Tuo L, Lee SM, Jin T, Liao S, Li W, Yan X, Sun CH. Amnibacterium endophyticum sp. nov., an endophytic actinobacterium isolated from Aegiceras corniculatum. Int J Syst Evol Microbiol. 2018 Apr;68(4):1327-1332 (IF=1.932; MICROBIOLOGY, Rank’g: 86/125)
  19. Quattrini A, Faircloth B, Duenas L, Bridge T, Brugler M, Calixto-Botia I, DeLeo D, Foret S, Herrera S, Lee SM, Miller D, Prada C, Radis-Baptista G, Ramirez-Portilla C Sanchez J, Rodriguez E, McFadden C. Universal target-enrichment baits for anthozoan (Cnidaria) phylogenomics: New approaches to long-standing problems. Mol Ecol Resour. 2018 Mar;18(2):281-295. (IF=7.1; EVOLUTIONARY BIOLOGY, Rank’g: 5/49)
  20. Liao Q, Li S, Siu SWI, Yang B, Huang C, Chan JY, Morlighem JRL, Wong CTT, Rádis-Baptista G, Lee SM*. Novel Kunitz-like Peptides Discovered in the Zoanthid Palythoa caribaeorum through Transcriptome Sequencing. J Proteome Res. 2018 Feb 2;17(2):891-902. (IF=3.95; BIOCHEMICAL RESEARCH METHODS, Rank’g: 14/79)
  21. Li FN, Tuo L, Pan Z, Guo M, Lee SM, Chen L, Hu L, Sun CH. Aureimonas endophytica sp. nov., a novel endophytic bacterium isolated from Aegiceras corniculatum. Int J Syst Evol Microbiol. 2017 Aug;67(8):2934-2940. (IF=1.932, MICROBIOLOGY, Rank’g: 87/126)
  22. Chan JY, Zhou H, Kwan YW, Chan SW, Radis-Baptista G, Lee SM. Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics. J Biochem Mol Toxicol. 2017 Nov;31(11). (IF=1.837; TOXICOLOGY, Rank’g: 71/94)
  23. Quattrini A, Faircloth B, Duenas L, Bridge T, Brugler M, Calixto-Botia I, DeLeo D, Foret S, Herrera S, Lee SM, Miller D, Prada C, Radis-Baptista G, Ramirez-Portilla C Sanchez J, Rodriguez E, McFadden C. Universal target-enrichment baits for anthozoan (Cnidaria) phylogenomics: New approaches to long-standing problems. Mol Ecol Resour. 2018 Mar;18(2):281-295. (IF=7.1; EVOLUTIONARY BIOLOGY, Rank’g: 5/49)
  24. Huang C, Morlighem JRL, Cai J, Liao Q, Perez CD, Gomes PB, Guo M, Rádis-Baptista G, Lee SM*. Identification of long non-coding RNAs in two anthozoan species and their possible implications for coral bleaching. Sci Rep. 2017 Jul 13;7(1):5333. (IF=4.122, MULTIDISCIPLINARY SCIENCES , Rank’g: 12/64)
  25. Fu Y, Li L, Hao S, Guan R, Fan G, Shi C, Wan H, Chen W, Zhang H, Liu G, Wang J, Ma L, You J, Ni X, Yue Z, Xu X, Sun X, Liu X, Lee SM*. Draft genome sequence of the Tibetan medicinal herb Rhodiola crenulata. Gigascience. 2017 Jun 1;6(6):1-5. (IF= 7.267; MULTIDISCIPLINARY SCIENCES, Rank’g: 7/64)
  26. Sun F, Fan G, Hu Q, Zhou Y, Guan M, Tong C, Li J, Du D, Qi C, Jiang L, Liu W, Huang S, Chen W, Yu J, Mei D, Meng J, Zeng P, Shi J, Liu K, Wang X, Wang X, Long Y, Liang X, Hu Z, Huang G, Dong C, Zhang H, Li J, Zhang Y, Li L, Shi C, WANG J, Lee SM, Guan C, Xu X, Liu S, Liu X, Boulos Chalhoub, Hua W, Wang H. The high-quality genome of Brassica napus cultivar ‘ZS11’ reveals the introgression history in semi-winter morphotype. Plant J. 2017 Nov;92(3):452-468. (IF=5.775; PLANT SCIENCES, Rank’g: 12/222)
  27. Guo M, Yang R, Huang C, Liao Q, Fan G, Sun C, Lee SM*. Evolutionary gradient of predicted nuclear localization signals (NLS)-bearing proteins in genomes of family Planctomycetaceae. BMC Microbiol. 2017 Apr 4;17(1):86. (IF=2.829; MICROBIOLOGY, Rank’g: 53/125)
  28. Huang C, Morlighem JR, Zhou H, Lima ÉP, Gomes PB, Cai J, Lou I, Pérez CD, Lee SM, Rádis-Baptista G. The Transcriptome of the Zoanthid Protopalythoa variabilis (Cnidaria, Anthozoa) Predicts a Basal Repertoire of Toxin-like and Venom-Auxiliary Polypeptides. Genome Biol Evol. 2016 Oct 5;8(9):3045-3064. (IF=4.098; GENETICS & HEREDITY, Rank’g: 42/171)
  29. Cao C, Lou I, Chen H, Lee SM, Metagenomic sequencing of activated sludge filamentous bacteria community using the Ion Torrent platform. Desalination and Water Treatment, 2016 Jan 26;57(5):2175-83. (IF= 1.29; ENGINEERING, CHEMICAL, Rank’g: 93/138)
  30. Tuo L, Pan Z, Li FN, Lou I, Guo M, Lee SM, Chen L, Hu L, Sun CH. riedmanniella endophytica sp. nov., an endophytic actinobacterium isolated from bark of Kandelia candel. Int J Syst Evol Microbiol. 2016 Aug;66(8):3057-62. (IF= 2.212; ICROBIOLOGY, 94/133)
  31. Tuo L, Li FN, Pan Z, Lou I, Guo M, Lee SM, Chen L, Hu L, Sun CH. Nakamurella endophytica sp. nov., a novel endophytic actinobacterium isolated from the bark of Kandelia candel. International Journal Of Systematic And Evolutionary Microbiology. 2016 Mar;66(3):1577-1582. (IF= 2.212, MICROBIOLOGY, Rank’g: 94/133)
  32. Huang C, Leung RK, Guo M, Tuo L, Guo L, Yew WW, Lou I, Lee SM*, Sun C*. Genome-guided Investigation of Antibiotic Substances produced by Allosalinactinospora lopnorensis CA15-2(T) from Lop Nor region, China. Sci Rep. 2016 Feb 11;6:20667. (IF=4.1; MULTIDISCIPLINARY SCIENCES, Rank’g: 12/64)
  33. Martinez Barrio A, Lamichhaney S, Fan G, Rafati N, Pettersson M, Zhang H, Dainat J, Ekman D, Höppner M, Jern P, Martin M, Nystedt B, Liu X, Chen W, Liang X, Shi C, Fu Y, Ma K, Zhan X, Feng C, Gustafson U, Rubin CJ, Sällman Almén M, Blass M, Casini M, Folkvord A, Laikre L, Ryman N, Lee SM, Xu X, Andersson L*, The genetic basis for ecological adaptation of the Atlantic herring revealed by genome sequencing, Elife 5 (2016).(IF=9.3; BIOLOGY, Rank’g: 4/85)
  34. Liu HM, Yang BR, Cheung XF, Yang KY, Zhou HF, Kwok JSL, Liu GC, Li XF, Zhong SL, Lee SM*, Tsui SKW*. Transcriptome analysis of leaves, roots and flowers of Panax notoginseng identifies genes involved in ginsenoside and alkaloid biosynthesis. BMC Genomics. 2015 Apr 3;16:265.(IF= 4.401; BIOTECHNOLOGY & APPLIED MICROBIOLOGY, Rank’g: 29/165 Top:17.58%)
Research Projects
External Grants or Contracts
  1. Development of topical application (eye drops) for the treatment of autoimmune-associated dry eye in patients with Sjögren’s Syndrome, funded by Macau Science and Technology Development Fund, 2019-2022, P.I.
  2. The research and development of PD-001, a novel anti-neurodegenerative natural compound, funded by Macau Science and Technology Development Fund, 2020-2023, P.I.
  3. High-throughput microfluidic fish screening system, funded by Macau Science and Technology Development Fund, 2018-2020, Co. I.
  4. New pharmacological mechanisms underlying molecular chaperone Hsp70-mediated morphine addiction, funded by National Natural Science Foundation of China, 2018-2021, Co. I.
  5. Discovery, pharmacology mechanism and structure-activity relationship investigation of anti-addiction rearranged iboga-type alkaloids from Ervatamia officinalis, funded by National Natural Science Foundation for Young Scientists of China, 2019-2021, Co. I.
  6. The research and development of PD-001, an anti-Parkinson’s disease agent, funded by Macau Science and Technology Development Fund, 2018-2020, P.I.
  7. Chemical composition and quality control of bamboo, funded by Panda Fund (Macau Government), 2017-2019, P.I.
  8. Genome-guided and mass spectrometry investigation of natural products produced by a potential new actinobacterial strain isolated from Macau mangrove ecosystem, funded by Macau Science and Technology Development Fund, 2017-2019, P.I.
  9. Discovery and therapeutic development of novel peptide toxins by transcriptomics and functional venomics, funded by Macau Science and Technology Development Fund, 2016-2019, P.I.
  10. Study on the Intestinal Microorganisms and Health of Giant Panda Using Next Generation DNA Sequencing, funded by Panda Fund (Macau Government), 2016-2017, P.I.
  11. Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment using in vitro and in vivo imaging models, funded by Health and Medical Research Fund, 2015-2017, Co. I.
  12. Pharmacological Elucidation of Novel Anti-Parkinson’s Leads from Chinese Medicines in Alpha-synuclein Transgenic Mouse and Zebrafish Models of Parkinson’s Disease, funded by Macau Science and Technology Development Fund, 2015-2018, P.I.
  13. Osteogenic Effects of Dietary Anthocyanins in Transgenic Medaka, funded by Department of Health and Human Services National Institutes of Health, 2015-2017, Co. I.
  14. Novel anti-Parkinson’s leads: pharmacological elucidation of multi-targeted neuroprotections by sunitinib analogs including the natural components from Chinese medicine, funded by Research Grants Council Earmarked Grants in Hong Kong, 2015-2017, Co. I.
  15. 發展及評估新型ROCK抑製劑在體外及斑馬魚及鼠體內的腦出血模型(深圳市中藥藥學及分子藥理學研究重點實驗室開放課題, 2013-2015, P. I.)
  16. 基於血管生成及腫瘤轉移相關優化“金復康”的研究 (上海市巿屬博士學科點建設基金, 2014, Co.I.)
  17. 基於斑馬魚平台結合多種模型系統研究三七花皂苷促血管新生作用及機制, funded by the National Science Foundation of China, 2014-2015, P. I.
  18. A study on synergistic bone anabolic effects of a combination use of Alendronate and Herba Epimedii in treating osteoporosis of ovariactomized rats, Health and Medical Research Fund, 2013-2015, Co. I.
  19. Unexpected anti-Parkinson’s neuroprotective and its molecular targets of Sunitinib, a clinical used anti-cancer drug, National Natural Science Foundation, 2013-2015, Co. I.
  20. 粵澳斑馬魚藥物篩選硏發平台的硏究(廣州市科技計劃項目, 2011-2012, Co. I.)
  21. Characterization, structural optimization and mechanistic study of the neuroprotective components from Chinese medicine for minimising and treating Parkinson’s disease complications, funded by Macau Science and Technology Development Fund, 2012-2015, P.I.
  22. Mechanistic studies of active compounds-combination from Chinese medicine for minimising and treating cardio-cerebrovascular complications, funded by Macau Science and Technology Development Fund, 2011-2014, P.I.
  23. Establishment of a DNA sequencing and bioinformatics analysis platform for genome and transcriptome analysis, funded by Macau Science and Technology Development Fund, 2009-2012, P.I.
  24. The theoretical pharmacology study on Chinese Herbs: Tianma and Gouteng (天麻、鉤藤歸經理論研究), funded by National Natural Science Foundation, 2009-2011, Co.I.
  25. The discovery and mechanism study of angiogenesis inhibitors from three Salvia herbal medicine, funded by National Natural Science Foundation, 2009-2011, Co. I.
  26. A study on molecular mechanism of anti-influenza virus effect of Chinese Medicine with second-generation DNA sequencing technology, funded by Open Research Grant-Guangzhou Institute of Respiratory Disease, 2009-2012, Co.I.
  27. Characterization and mechanistic study of the bioactive components from selected Chinese medicine for proangiogenic and neuroprotective activities, funded by Macau Science and Technology Development Fund, 2008-2011, P. I.
  28. Characterization and mechanistic study of the bioactive components from selected Chinese medicine for anti-cancer activities using system biology approach, funded by Macau Science and Technology Development Fund, 2008-2011, Co. I.
  29. Study on the active ingredients and mechanism of action of Chinese medicine on treatment of atherosclerosis, funded by Macau Science and Technology Development Fund, 2006-2008, P.I. with Prof YiTao Wang.
  30. Characterization and mechanistic study of the bioactive components from TCM for the anti-proliferative Effect on Human Hepatoma Cells in vitro and in vivo, funded by Macau Science and Technology Development Fund, 2006-2007, P. I.
  31. Study of the effects of Herba Epimedii (Yinyanghuo) and Fructus Ligustri Lucidi (Nvzhenzi) on bone and mineral metabolism, funded by Research Grants Council Earmarked Grants in Hong Kong, 2004-2006, Co. I.
  32. Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis, funded by Research Grants Council Earmarked Grants in Hong Kong, 2003-2006, Co.I.
Community Services
  • Member, Commission of Experts and Consultants for the Appraisal of Proprietary Chinese Medicines, Macao Government 澳門藥物監督管理局《中成審評專家顧問委員會》成員
  • Associate editor of Frontiers in Pharmacology – Cardiovascular and Smooth Muscle Pharmacology (2010-present) 期刊《Frontiers in Pharmacology 》— Cardiovascular and Smooth Muscle Pharmacology副主編
  • Editorial board member, The Federation of American Societies for Experimental Biology and Wiley Announce Publishing Partnership — FASEB BioAdvances (2017.5-present)《FASEB BioAdvances》編輯委員會 成員
  • Editorial board member of Chinese Medicine (2013-present) 期刊《Chinese Medicine》編輯委員會 成員
  • Member, WHO Collaborating Centre for Traditional Medicine (Macao) 世界衛生組織傳統醫藥合作中心（澳門）委員
  • Technical expert of an ISO/IEC 17025 accreditation assessment. Innovation and Technology Commission (ITC), Hong Kong SAR Government (2012-2015). 香港創新科技署ISO/IEC 17025認證評審 技術專家
  • Member of the Board of Directors, Good Practice in Traditional Chinese Medicine Research Association 中醫藥規範研究學會 委員
  • Executive Editor, Newsletter of Good Practice in Traditional Chinese Medicine Research Association
  • 《中醫藥規範研究學會電子通訊期刊》 執行總編輯
  • Committee Member, Division of Neuropsychopharmacology, Chinese Pharmacological Society 中國藥理學會神經精神藥理學專業委員會 委員
  • President of Director Board, Consortium of ‘Belt and Road’ and Portuguese-Speaking Countries for Natural Medicine Innovation (Macao) 「一帶一路」及葡語系國家天然藥物創新聯盟（澳門） 理事長
  • Invited Committee Member, China Association for Science and Technology 廣東省科學技術協會 特邀委員
  • Consultant, Guangdong Provincial Association for Science and Technology 珠海市科學技術協會 顧問
  • Chairman, Macau Pharmacology Association 澳門藥理協會 會長
  • Committee Member of the Fourth Board, Integration of traditional Chinese medicine and western Medicine Subgroup, China Association of Gerontology and Geriatrics 中國老年學和老年醫學學會中西醫結合分會 第四屆常務委員
  • Board member, Academic Subgroup of Free Radical Biology and Free Radical Medicine, Biophysical Society of China 中國生物物理學會自由基生物學與自由基醫學分會 理事
  • Committee member, Chinese Medicine and Natural Medicine Pharmacology, Chinese Pharmacological Society (2019.10-present) 中國藥理學會中藥與天然藥物藥理專業委員會 第八屆委員會委員
  • Committee member, Committee of Neuropharmacology, Chinese Pharmacological Society (2018.10-present) 中國藥理學會神經精神藥理學專業委員會 第十五屆專業委員會委員
  • Founder member of BioEdu programme, funded by Education and Youth Development Bureau, Macau SAR Government. (2007-present) 普及生物技術教學實驗計劃(教育及青年發展局資助) 創始人
  • Vice President of Director Board, Macao Association for Promotion of Science and Technology (2013-present). 澳門科學技術協進會 副理事長
  • Macao-PISA 2008 Science Education Study for Education and Youth Development Bureau, Macau SAR Government. 教育及青年發展局2008澳門PISA科學教育研究
  • Board Member of International Society for Chinese Medicine (2012-present). 國際中醫藥學會 理事
  • General Supervisory Board of Zhuhai UM Science & Technology Research Institute
  • (ZUMRI) (2020-present) 珠海澳大科技研究院監事會 監事
Selected Awards and Honors
2020
  • Science and Technology Award-3rd Technological Invention Award (The Government of Macao Special Administrative Region), Project: A High Throughput Zebrafish Screening System 澳門科學技術奬–技術發明奬三等奬:項目名稱《用於藥物研發和環境監測的基於微流控技術大規模活生物體篩選系統》
  • Science and Technology Award-3rd Technological Invention Award (The Government of Macao Special Administrative Region), Project: Environmental Friendly Pesticide 澳門科學技術奬–技術發明奬三等奬:項目名稱《環境友好百草枯新劑型的開發》
  • Shanghai Science and Technology Progress Award Second Prize 上海市科技進步獎二等獎:項目名稱《動脈粥樣硬化“虛致痰瘀”的演變機制及其相關心血管疾病的防治研究》
  • Shanghai Science and Technology Award of Integrative Medicine Third Prize 中國中西醫結合學會科學技術獎三等獎:項目名稱《心血管疾病斑馬魚模型體系構建及中醫藥防治作用的研究》
2019
  • 1st Prize Award, Chinese Association of Integrative Medicine 中國中西醫結合學會心血管專業委員會科技獎一等獎:項目名稱《心血管疾病斑馬魚模型體系構建及中醫藥防治作用的研究》
  • Gold Medal with the Congratulations of Jury, jointly organized by the World International, Intellectual Property Organization and the federal government of Switzerland, the International Exhibition of Inventions of Geneva, SWITZERLAND 第47屆瑞士日內瓦國際發明展評判特別嘉許金獎：項目名稱“基於微流控技術的班馬魚篩選系統”,組織者“國際智慧財產權組織（WIPO）和瑞士聯邦政府”
  • Top 50 Projects of the High-value Patent Cultivation and Layout Competition in Guangdong-Hong Kong-Macao Greater Bay Area in 2019, Intellectual Property Office, The Zhuhai Municipal People’s Government and Hengqin International Intellectual Property Exchange Center, CHINA 《基於微流控技術的大規模活生物體及細胞篩選系統》獲得2019年粵港澳大灣區高價值專利培育佈局大賽 50強Incentive Award Scheme for Outstanding Academic Staff 2018/2019, University of Macau
  • 2020/2021學年教學人員年度獎勵計劃奬項, 澳門大學
2017
  • Shanghai Science and Technology Award of Integrative Medicine 中國中西醫結合學會科學技術獎：項目名稱“三七花有效組分心血管保護作用的發現及保護作用機制的研究”，獎勵等級“二等獎”，組織者“中國中西醫結合學會”，證書號“20170302A”
  • Shanghai Science and Technology Award上海市科學技術獎：項目名稱“三七花有效組分心血管保護作用的發現及保護作用機制的研究”，獎勵等級“三等獎”，組織者“上海市人民政府”，證書號“20174116-3-R04”
  • Second Prize: the zebrafish In Vivo Chip Platform in the “Cross Straits, Hong Kong and Macau Collaborative Innovation Roadshow Competition”, organized by the Government of Macau, SAR 2017海峽兩岸暨港澳協同創新路演大賽二等奬
2016
  • Shanghai Science and Technology Award of Integrative Medicine上海中西醫結合科學技術獎：項目名稱“三七花有效組分心血管保護作用的發現及作用機制的研究”，獎勵等級“二等獎”，組織者“上海市中西醫結合學會”，證書號“2016-13A-03”
  • Science and Technology Award-2nd Natural Science Award (The Government of Macao Special Administrative Region): Association Study of Pharmacology and Quality in Chinese Medicine 澳門科學技術奬–自然科學奬二等奬:項目名稱《中藥質量評價關鍵科學問題的基礎研究及其應用》
2011
  • UM Academic Staff Award, University of Macau教學人員奬項, 澳門大學
2012
  • Science and Technology Award-2nd Natural Science Award (The Government of Macao Special Administrative Region): Association Study of Pharmacology and Quality in Chinese Medicine 澳門科學技術奬–自然科學奬二等奬:項目名稱《中藥質量評價關鍵科學問題的基礎研究及其應用》
  • The 16th Chinese Pharmacological Society Servier Award for young Investigator in Pharmacology, Chinese Pharmacological Society and French Servier Research Institute 第十六屆中國藥理學會SERVIER青年藥理工作者奬
2009
  • Popular Science Award: Project entitled “Application of zebrafish in drug screening for treatment of cardiovascular diseases” is selected as the most popular research projects in “Science is by your side: Vote for Your Favourite Local Science Researches”, organized by Macao Science Center 澳門科學館最受歡迎研究項目奬
  • UM Faculty Service Award, University of Macau 學院服務獎,澳門大學
Patents
  • Microfluidic screening system

US Patent Pub. No.: US10392592B2; Pub. Date: 08/27/2019
European Patent Pub. : EP3321681A1; Pub. Date: 16/05/2018
基於微流控技術的大規模活體生物篩選系統
中國專利號：CN106885807B; 授權公告日:24/04/2020

 

  • Novel Anti-Neurodegenerative Natural Compounds Isolated from Alpiniae Oxyphyllae Fructus and Their Total Synthesis

US Patent Pub. No.: US9475749B2; Pub. Date: 25/10/2016
European Patent Pub. No.: EP2970090B1; Pub. Date: 08/05/2019
Japan Patent Pub. No.: JP6422452B2; Pub. Date: 14/11/2018
Spain Patent Pub. No: ES2736599T3; Pub. Date: 03/01/2020
分離自益智仁的新抗神經變性天然化合物及其全合成
中國專利號: CN105431405B; 授權公告日: 01/06/2018

 

  • Uses Of Indole-Ketones Or Indolidones As Neuro-Protective Drugs

International PCT Pub. No: WO2013061279A4; Pub. Date: 2/5/2013
US Patent Pub. No.: US9486440B2; Pub. Date: 08/11/2016
吲哚酮類化合物在製備神經保護藥物中的應用
中國專利號: CN102499917B; 授權公告日: 17/12/2014

 

  • Composition For Treating Dry Eye Diseases And Sjögren’s Syndrome

International PCT Pub. No: WO2017033060A1; Pub. Date: 02/03/2017
US Patent Pub. No.: US11007177B2; Pub. Date: 18/05/2021
用於治療乾眼病和斯耶格倫氐綜合症的組合
中國專利號: CN107921022B; 授權公告日: 01/06/2021

 

  • 一種用於治療肺癌的藥物組合物

中國專利號: CN105030746B; 授權公告日: 10/11/2017

 

  • 一種用於腦神經保護的藥物的組合

中國專利號: CN102526021B; 授權公告日: 11/09/2013

 

  • 用於篩選抗血管損傷藥物的斑馬魚血管損傷模型及其建立方法和應用

中國專利號: CN102499135B; 授權公告日:14/08/2013

 

  • 4,7-二氫四唑[1,5-á]嘧啶類化合物及其衍生物在製備預防或治療腦出血藥物中的應用

中國專利號: CN103193780B; 授權公告日:08/07/2015

 

  • 三七花總皂苷在制備促進血管新生的藥物中的應用

中國專利號: CN103893230B; 授權公告日:20/07/2016

Selected News

 

 

 

 

  • 研發新藥拓海外市場(2022) http://www.macaodaily.com/html/2022-08/05/content_1613227.htm

 

 

 

 

 

  • 李銘源分享創作科普書心得(2022) 《現代澳門日報》

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  • 《澳門普及生物技術教學實驗手冊－－斑馬魚在醫藥研究的應用》主編：李銘源；出版：澳門科學技術協進會；出版日期：2018年6月；ISBN 978-99937-691-5-6 http://osmacanese.com/期刊/

 

 

 

 

 

 

 

 

 

 

Selected Interviews/Videos
澳廣視【創科世界】– 澳大以科技助本地傳統中成藥發展

電視節目《東張西望》– 澳大創新創業 (2019)

Research Projects at UM : Microfluidic Screening System (2019)【澳大研究】微流控藥物檢測儀
電視節目《東張西望》介紹澳門大學國家重點實驗室 (2019)

UM Develops Lab Device to Promote Zebrafish’s Value in Scientific Research (2018) 澳大升級斑馬魚成像儀推廣到市場

UM Develops Medicine from Yi Zhi Ren to Treat Parkinson’s Disease (2018)澳大研發中藥益智仁治療柏金遜症

 

Macau STEAM Lab，創始人：李銘源

 

珠海電視報導澳門大學中華醫藥研究院的最新發展，並訪問了該院的李銘源教授、博士生鍾章鋒和楊彬睿 (2015)
Contact Details

Prof. Simon Ming Yuen LEE
李銘源 教授
Chair Professor in Biomedical Sciences / 講座教授(生物醫學)
Department of Food Science and Nutrition / 食品科學及營養學系
Email: [email protected]
Office: (852) 3400 883
https://www.polyu.edu.hk/fsn/people/academic-staff/prof-lee-mingyuen-simon/

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